Wednesday, May 6, 2020

The primitive method of DNA

Question: Why do you think sequencing has garnered more attention/buzz than other technologies? Are there other technologies that are equally deserving of attention? Answer: Introduction The primitive method of DNA sequencing or the Sanger sequencing has been carried out since the 1990s. After the sequencing of DNA is done enormous amounts of profiling through advanced technologies are carried out. The process is totally dedicated to the better understanding of inherited diseases and genetic disorders. Single nucleotide polymorphisms or SNPs are the variation in DNA sequences that occurs when a single nucleotide in the sequence is altered. These SNPs are the most important tool in sequencing as they are responsible for the susceptibility of diseases in human body, the effects of drugs sensitivity or resistance and for the wellbeing of every human being. These databases of SNPs provide the data to further research effects of genetic diseases, or certain drugs on humans(Orapan Sripichai PhD,Suthat Fucharoen MD, 2007). Alternative Technology The alternative second generation DNA sequencing technique has arrived in recent time that have reduced the cost of sequencing by two times and saves more energy. Some of the methods are micro electrophoretic method, cyclic array sequencing, sequencing by hybridization. Another researcher John Chapaut, a researcher at ASUs bio design laboratory along with some scientists from England , Belgium ,Denmark answered a long debated question that whether there are any other heredity and evolution molecule other than DNA and RNA. They have found evolution threose nucleic acid to xenonucleic acids or XNA. The method of producing XNA greatly improves the accuracy and efficiency of the evolution of polymerase. Though it is still in research phase(Richard Harth, 2012). Conclusion The genome research or genome sequencing has created a buzz and acquired attention because it had been the first technology to have shown such a huge promise to humanity that it will change their lives and give them hope for a better living and although many technologies has arrived after that, but still sequencing had been like a first step on the moon for biologists.

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